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KMID : 0061119810090000056
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Bulletin of the Clinical Research Institute
1981 Volume.9 No. 0 p.56 ~ p.56
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Topographic Variance of Contact Sensitivity Reaction in Guinea Pigs
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Kim Jin-wou
Houh Won
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Abstract
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There have been published manuscripts which fully suggest that there may be a topographic variance of contact sensitivity in experimental animals such as guinea pigs, hamsters and mice, probably due to a large extent to the topographic difference of Langerhans cell population and to a little extent to impact on the induction site.
This assay was done to establish the possibility of involvement of a certain topographic variance in contact sensitivity reaction.
Three different anatomical sites were chosen for the induction in three groups of five guinea pigs the conventional siteof the nuchal region, and the sacral and abdominal skin regions. For the elicitation, two different concentrations of DNCB were applied on three sites along both sides of the spine in the back.
The contact sensitivity reactions elicited by DNCB in the group of the nuchal and abdominal skin induction were definitely stronger at the site closer to the nuchal region than that found at site closer to the sacral region, but all animals of the group sensitized on the sacral region showed comparatively uniform reaction. Evidently, contact sensitivity reaction is influenced mainly by topographic variance but shows a little difference depending upon induction sites.
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